Aktivitas Imunostimulan Ekstrak Metanol Biji Kurma (Phoenix dactylifera) secara In Silico Terhadap Reseptor GIF dan COX-2 serta Uji In Vitro melalui Proliferasi Sel Limfosit Mencit

Dates (Phoenix dactylifera) is one of the plants that very useful, but date palm seeds become waste have not been widely used. Based on studies are known to contain bioactive compounds can be suspected as antioxidants, antimicrobials and anti-inflammatory. However, research immunostimulants from dates, especially in silico vitro, has carried out. Therefore, this study aims determine potential seed through against Human Glycosylation-Inhibiting Factor (1GIF) Cyclooxygenase-2 (5IKR) receptors well vitro proliferation lymphocyte cells male mice (Mus musculus) balb/c strains with MTT Assay methods. The results showed 5-O-Caffeoylshikimic Acid had highest interaction stability, Gibbs free energy 1GIF 5IKR receptors, -6.68 kcal/mol -8.58 kcal/mol, respectively. This value higher than Caffeic control ligand. obtained methanol extract at a concentration series 6.25; 12.5; 25 µg/mL cell activity which was indicated by an increasing OD value, μg/mL produces immunostimulant activity. containing compound potentially agent.